It doesn't look like Maguire will feature, which is a blow for United, but I just can't see them losing anyway.
I'd expect Eric Bailly to come in and partner Victor Lindelof at the back because of his experience. He will also know a lot about Villarreal because he used to play for them.
They will be weaker without Maguire but I don't think it will matter because they have so many match-winners and they also have a winning mentality too.
My prediction: United to win 2-0. It might be closer than that, but they will be stronger on the bench if they need to make any changes, and they will find a way to win.